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Millipore This Anti-Nb Thymosin Beta (Tmsb15a Antibody), Clone 4a6.3 Is Validated For Use In Immunohistochemistry (Paraffin) For The Detection Of Nb Thymosin Beta (Tmsb15a). - Mill (Additional S&H or Hazmat Fees May Apply)
TMSB15A protein is a key regulator of the cytoskeleton organization and polymerization, and it thus plays a role in cell migration, proliferation and cancer. TMSB15A does this because TMSB15A binds to and sequesters actin monomers and limits action polymerization. TMSB15A is differentially expressed in many tissues and cancer cell lines. Because of differential expression in certain cancers, for instance in triple negative breast cancer but not colon cancer, TMSB15A is being examined as a histochemical marker for measuring the effectiveness of cancer therapy on cancer. TMSB15A is also important in the nervous system and brain diseases. Notably, TMSB15A expression is increased upon brain stress and surprisingly TMSB15A localization differs depending upon the type of stress used and neuronal cell type. Because of its interaction with actin, TMSB15A is localized to the cytoplasm most of time, however, in the brain and when cells are placed under various stresses, TMSB15A can be translocated to the brain to perform yet unknown functions as well.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-NB thymosin beta (TMSB15A Antibody), Clone 4A6.3 is validated for use in Immunohistochemistry (Paraffin) for the detection of NB thymosin beta (TMSB15A).
Key Applications
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human thalamic and human brain cancer tissues.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to Human TMSB15A.
Clone
4A6.3
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgMκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_068832
Gene Symbol
TMSB15A
TMSL8
TMSNB
UniProt Number
P0CG34
Molecular Weight
5 kDa calculated
Product Usage Statements
Quality Assurance
Evaluated by Immunohistochemistry in human cerebral cortex tissue.
Immunohistochemistry Analysis: A 1:50 dilution from a representative lot detected TMSB15A in human cerebral cortex tissue
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
