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Millipore Anti-Gata2 Antibody, Clone 3c10.1, Cat. No. Mabs1814, Is A Mouse Monoclonal Antibody That Targets Gata2 And Has Been Tested In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Endothelial transcription factor GATA-2 (UniProt: P23769; also known as GATA-binding protein 2) is encoded by the GATA2 gene (Gene ID: 2624) in human. GATA2 is a zinc-finger transcriptional activator that regulates endothelin-1 gene expression in endothelial cells. It binds to the consensus sequence 5-AGATAG-3. GATA2 is expressed in embryonic brain and liver, endothelial cells, and in erythroid cells. GATA2 mutations appear to cause loss of function of the mutated allele leading to haploinsufficiency, which results in immunodeficiency characterized by significantly reduced or absent monocytes, B-lymphocytes, natural killer lymphocytes, and circulating and tissue dendritic cells. However, it does not affect the T-cell number. This deficiency leads to increased susceptibility to mycobacterial, papillomavirus, and opportunistic fungal infections. Certain mutations in GATA2 are also linked to lymphedema that results in swelling of the extremities due to altered lymphatic flow.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-GATA2 Antibody, clone 3C10.1, Cat. No. MABS1814, is a mouse monoclonal antibody that targets GATA2 and has been tested in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST/His-tagged recombinant fragment corresponding to 114 amino acids from the internal region of human GATA2.
Clone
3C10.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 3C10.1 specifically detects Endothelial transcription factor GATA-2 in human. It targets an epitope within 114 amino acids from the internal region.
Isotype
IgG2bκ
Species Reactivity
Human
Species Reactivity Note
Human. Predicted to react with Mouse based on 100% sequence homology.
Antibody Type
Monoclonal Antibody
Gene Symbol
GATA2
Purification Method
Protein G purified
UniProt Number
P23769
Molecular Weight
~52 kDa observed; 50.50 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in SH-SY5Y cell lysate. Western Blotting Analysis: A 1:1,000 dilution of this antibody detected GATA2 in 10 µg of SH-SY5Y cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
