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Millipore Anti-PEG, Clone 6.3, Cat. No. Mabs1966, Is A Mouse Monoclonal Antibody That Detects PEG-Conjugated Proteins And It Hs Been Tested For Use In ELISA. - Mill (Additional S&H or Hazmat Fees May Apply)
Polyethylene glycols (PEG) are non-toxic, uncharged, hydrophilic long chain polymers with a big exclusion volume in aqueous solution. The covalent attachment of PEG is commonly employed to modify proteins and drugs that can increase their bioavailability and reduce immunogenicity and proteolytic degradation. Clone 6.3 displays high affinity and binds the PEG backbone and can be employed as a detection antibody for the quantification of PEG. It binds to a smaller epitope of the PEG backbone when compared to other antibodies. Since it binds to a smaller PEG epitope (~750 Da), it is not compatible with detergents that contain an ethylene oxide backbone, such as Tween 20. Instead 0.05% CHAPS is a more suitable detergent when using this antibody.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal antibody IgG1 in PBS with 0.04% sodium azide.
Applications
Application
Anti-PEG, clone 6.3, Cat. No. MABS1966, is a mouse monoclonal antibody that detects PEG-conjugated proteins and it hs been tested for use in ELISA.
Key Applications
ELISA
Application Notes
ELISA Analysis: A representative lot detected PEG in ELISA applications (Tung, H.Y., et. Al. (2015). Mol Cancer Ther. 14(6):1317-26).
Biological Information
Immunogen
PEG-conjugated to E.coli beta-glucuronidase.
Clone
6.3
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 6.3 specifically detects proteins conjugated with polyethylene glycol (PEG).
Isotype
IgG1κ
Species Reactivity
All
Species Reactivity Note
All.
Antibody Type
Monoclonal Antibody
Purification Method
Protein A purified
Molecular Weight
N/A
Product Usage Statements
Quality Assurance
Evaluated by ELISA in Immobilized PEG (10K-PEG, 3K-PEG, and 2K-mPEG).
ELISA Analysis: 5 µg/mL of Immobilized PEG (10K-PEG, 3K-PEG, and 2K-mPEG) were detected with this antibody.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
