The store will not work correctly when cookies are disabled.
We use cookies to make your experience better.To comply with the new e-Privacy directive, we need to ask for your consent to set the cookies. Learn more.
NETA ALERT: Due to inclement weather our offices are closed today, Monday Feb. 23. We will not be shipping orders.
Millipore Anti-P40 Antibody, Clone 11f12.1 Is An Antibody Against P40 For Use In Ihc (Paraffin) & Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
P40, also known as Tumor protein 63, p63, Chronic ulcerative stomatitis protein, CUSP, Keratinocyte transcription factor , KET, Transformation-related protein 63, TP63, Tumor protein p73-like, p73L, p40, or p51, and encoded by the gene TP63/KET/P63/P73H/P73L/TP73L, is a transcriptional activator or repressor depending upon the target gene and the isoform involved. P40 has multiple isoforms. P40 is involved in Notch signaling and plays a role in p53/TP53 dependent apoptosis and epithelial morphogenesis. Moreover P40, developmentally, is required for proper limb formation. P40 is widely expressed in the adult and during development. Some isoforms, such as isoform 10 are primarily expressed in cancerous tissues while others are found only in normal tissues. Mutations in P40 lead to a variety of dysplasias and malformations, including Acro-dermato-ungual-lacrimal-tooth syndrome and Ankyloblepharon-ectodermal defects cleft lip/palate disorder and several more tragic disfiguring syndromes.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
Anti-P40 Antibody, clone 11F12.1 is an antibody against P40 for use in IHC (Paraffin) & western blotting.
Key Applications
Immunohistochemistry (Paraffin)
Western Blotting
Application Notes
Immunohistochemistry Analysis: A 1:500-2,000 dilution from a representative lot detected P40 in human prostate and human kidney tissue.
Biological Information
Immunogen
KLH-conjugated linear peptide corresponding to human P40.
Clone
11F12.1
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Isotype
IgG2aκ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_001108450
Gene Symbol
TP63
KET
P63
P73H
P73L
TP73L
Purification Method
Protein G Purified
UniProt Number
Q9H3D4
Molecular Weight
~40 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in SK-OV-3 cell lysate.
Western Blotting Analysis: 2.0 µg/mL of this antibody detected P40 in 10 µg of SK-OV-3 cell lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
