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Millipore This Anti-Parvin Alpha Antibody, Clone 7e2.1 Is Validated For Use In Western Blotting & Ihc (Paraffin) For The Detection Of Parvin Alpha. - Mill (Additional S&H or Hazmat Fees May Apply)
Calponin-like integrin-linked kinase-binding protein
Matrix-remodeling-associated protein 2
Background Information
The protein named α-Parvin or Parvin, or Actopaxin, or Calponin-like integrin-linked kinase-binding protein (CH-ILKBP), or Matrix-remodeling-associated protein 2 (MXRA2), and encoded by the gene PARVA/MXRA2, is a critical adhesion coupling protein involved in many systems including sarcomere organization, smooth muscle contraction, cardiovascular development, angiogenesis, actin cytoskeleton organization and the establishment of cell polarity, adhesion, spreading and migration. α-Parvin is required for the adhesion of smooth muscle cell to endothelial cells during blood vessel development and for the formation of lamellipodia and ciliogenesis. α-Parvin is localized to the cell junction and focal adhesions. The protein is peripheral membrane protein located on the cytoplasmic side of the cell membranes and interacts with the cytoskeleton in the cytoplasm. In muscle cells it is associated with the Z line of the sarcomere. α-Parvin is expressed many tissues including muscle, kidney and liver.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Quality Level
MQ100
Applications
Application
This Anti-Parvin alpha Antibody, clone 7E2.1 is validated for use in western blotting & IHC (Paraffin) for the detection of Parvin alpha.
Key Applications
Western Blotting
Immunohistochemistry (Paraffin)
Application Notes
Immunohistochemistry Analysis: A 1:2,000 dilution and a 1:50 dilution from a representative lot detected Parvin alpha in human kidney and skeletal muscle tissues, respectively.
Biological Information
Immunogen
GST-tagged recombinant protein corresponding to human Parvin.
Clone
7E2.1
Concentration
Please refer to the Certificate of Analysis for the lot-specific concentration.
Host
Mouse
Isotype
IgG1κ
Species Reactivity
Human
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_060692
Gene Symbol
PARVA
MXRA2
Purification Method
Protein G Purified
UniProt Number
Q9NVD7
Molecular Weight
~42 kDa observed
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human heart tissue.
Western Blotting Analysis: 0.2 µg/mL of this antibody detected Parvin alpha in 200 µg of human heart tissue.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
