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Millipore Anti-Myomesin-2, Clone 3b9.3, Cat. No. Mabt94, Is A Mouse Monoclonal Antibody That Detects Human Myomesin-2 And Has Been Tested For Use In Western Blotting. - Mill (Additional S&H or Hazmat Fees May Apply)
Myomesin-2 (UniProt: P54296; also known as 165 kDa connectin-associated protein, 165 kDa titin-associated protein, M-protein, Myomesin family member 2) is encoded by the MYOM2 gene (Gene ID: 9172) in human. Myomesin-2 is a major component of the vertebrate myofibrillar M band and is mainly expressed in fast fibers. It binds myosin, titin, and light meromyosin in a dose-dependent manner. Its primary function is to upkeep M-band filament lattice. It has a unique N-terminal domain followed by 12 repeat domains with strong homology to either fibronectin type III or immunoglobulin C2 domains. Myomesin-2 is shown to interact with dysferlin, a protein that aids in repairing the sarcolemma when it is damaged or torn due to muscle strain and assists in myofibril stability.
Product Information
Format
Purified
Presentation
Purified mouse monoclonal antibody IgG2a in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Applications
Application
Anti-Myomesin-2, clone 3B9.3, Cat. No. MABT94, is a mouse monoclonal antibody that detects human Myomesin-2 and has been tested for use in Western Blotting.
Key Applications
Western Blotting
Biological Information
Immunogen
GST-tagged recombinant fragment corresponding to 154 amino acids from the N-terminal region of human Myomesin-2.
Clone
3B9.3
Concentration
Please refer to lot specific datasheet.
Host
Mouse
Specificity
Clone 3B9.3 detects human muscle Myomesin-2. It targets an epitope with in the N-terminal half.
Isotype
IgG2aλ
Species Reactivity
Human
Species Reactivity Note
Human.
Antibody Type
Monoclonal Antibody
Entrez Gene Number
NP_003961
Gene Symbol
MYOM2
Purification Method
Protein G purified
UniProt Number
P54296
Molecular Weight
~165 kDa observed; 164.90 kDa calculated. Uncharacterized bands may be observed in some lysate(s).
Product Usage Statements
Quality Assurance
Evaluated by Western Blotting in human skeletal muscle tissue lysate.
Western Blotting Analysis: 0.05 µg/mL of this antibody detected Myomesin-2 in human skeletal muscle tissue lysate.
Usage Statement
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
