Miltenyi Biotec Identification and Enumeration of Irf-7 Ps477/Ps479+ Cells By Flow Cytometry; 100 Tests in 200 µL

Miltenyi Biotec Clone REA310 recognizes the interferon regulatory factor 7 (IRF-7) phosphorylated at serines 477 and 479 (pS477/pS479). IRF-7 is a member of the IRF family of transcription factors and a key player in the innate immune response against viral infections. Constitutive expression of IRF-7 is limited to peripheral blood lymphocytes and dendritic cells while in most cell types its expression can be induced by type I interferon. IRF-7 is sequestered in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling, it becomes phosphorylated by TBK and IKK-i kinases. Phosphorylated IRF-7 migrates in the nucleus where it can activate interferon type I genes and other interferon-stimulated genes. | Additional information: Clone REA310 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)