Miltenyi Biotec Identification and Enumeration of Cd278 (Icos)+ Cells By Flow Cytometry; 100 Tests in 200 µL

Miltenyi Biotec Clone REA192 recognizes CD278 (ICOS), which belongs to the CD28 family of proteins. CD28 family members are costimulatory receptor molecules, contain single immunoglobulin V-like domain, and belong to the immunoglobulin superfamily. CD287 recognizes inducible T cell costimulator ligand (ICOSL) as ligand and its expression is induced on activated T cells. Enhanced expression of CD278 is also observed on T cells, followed by costimulation of T cells via CD28. Further expression of CD278 is found on B cells, monocytes, and dendritic cells. Crosslinking of ICOS on T cell surface in the presence of primary stimulation signal leads to T cell proliferation and differentiation. In addition, CD278 plays role in Tʜ cell differentiation, effector T cell function, and isotype class switching. | Additional information: Clone REA192 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)