Miltenyi Biotec Recombinant Antibody For The Detection of Cd163+ Cells; 200 µL

Miltenyi Biotec Clone REA1309 recognizes the human CD163 antigen, a single-chain transmembrane protein also known as hemoglobin scavenger receptor or M130. It is expressed by mature tissue macrophages and peripheral blood monocytes. The expression of CD163 is up-regulated in vitro and in vivo by anti-inflammatory mediators such as IL-10 and (gluco)corticosteroid and is shed to blood upon inflammatory activation of macrophages. CD163 functions as a high affinity scavenger receptor for the complex of haemoglobin and haptoglobin. Depending on the ligand, crosslinking of CD163 initiates signal transduction leading to the production of proinflammatory cytokines Il-1ß, IL-6, and GM-CSF or the anti-inflammatory cytokine IL-10. | Additional Information: Clone REA1309 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)