Miltenyi Biotec Identification and Enumeration of Cd85d (Ilt4)+ Cells By Flow Cytometry; 30 Tests in 60 µL

Miltenyi Biotec Clone REA184 recognizes CD85d, also known as immunoglobulin-like transcript 4 (ILT4) or leukocyte Ig-like receptor 2 (LIR2). CD85d is an inhibitory immunoreceptor, expressed mainly on myelomonocytic lineage cells. | CD85d has four tandem Ig-like extracellular domains and three immunoreceptor tyrosine-based inhibitory receptor motifs in its cytoplasmic tails, which recruit the tyrosine phosphatase Src homology 2 domain containing phosphatase 1 (SHP-1). It has been shown that CD85d interacts with HLA-A, -B, -G1, and -E molecules as ligands. HLA-g expression is restricted to trophoblasts and thus interaction of CD85d with HLA-g is suggested to inhibit placental leukocytes, contributing to maternal tolerance of the fetal semiallograft. | Additional information: Clone REA184 displays negligible binding to Fc receptors. | - MLTY (Additional S&H or Hazmat Fees May Apply)