Miltenyi Biotec Identification and Enumeration of Hla-E+ Cells By Flow Cytometry; 100 Tests in 200 µL

Miltenyi Biotec Clone REA1031 recognizes the human HLA-E protein, a member of the human leukocyte antigen family. HLA-E is a non-classical MHC molecule (MHC-Ib) with limited polymorphisms, which is expressed on the cell surface in a heterodimeric complex with β2-microglobulin. HLA-E is ubiquitously expressed and has a specialized role in NK cell recognition. It binds a restricted set of peptides, e.g., derived from other class I leader sequences. The complex is recognized by NKG2A on natural killer (NK) cells. This recognition protects the HLA-E–expressing cell from NK cell killing. Recently HLA-E recognition by a specialised subset of CD8 T cells has been implicated in pathogen recognition as well as autoimmunity. | Additional information: Clone REA1031 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)