Miltenyi Biotec Identification and Enumeration of Cd106 (Vcam-1)+ Cells By Flow Cytometry; 30 µg in 200 µL

Miltenyi Biotec Clone REA971 recognizes the mouse CD106 antigen, a 110 kDa single-chain type I glycoprotein, also known as vascular cell adhesion protein 1 (VCAM-1). CD106 is expressed on bone marrow cells, stromal cells, and inflamed vascular endothelium as well as on macrophage-like and dendritic cell types in both normal and inflamed tissue. Upregulation of CD106 in endothelial cells by inflammatory stimuli and cytokines occurs as a result of increased gene transcription. Primarily, CD106 is an endothelial ligand for very late antigen-4 (VLA-4) or integrin α-4/β-7 and mediates both adhesion and signal transduction. The interactions play a pathophysiologic role in leukocyte adhesion, transmigration, and co-stimulation of T cell proliferation. | Additional information: Clone REA971 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)