Miltenyi Biotec Identification and Enumeration of Cd152+ Cells By Flow Cytometry; 30 µg in 200 µL

Miltenyi Biotec Clone REA984 recognizes the mouse CD152 antigen, also known as cytotoxic T lymphocyte antigen-4 (CTLA-4), which is a 33 kDa member of the immunoglobin superfamily and is expressed on activated T cells at a low level. CTLA-4 and CD28 have similarities concerning B7 family counter-receptors. While CD28 delivers a co-stimulary signal in T cell activation, CD152 restricts the progression of T cells to an activated state by inhibiting interleukin 2 (IL-2) secretion and cellular proliferation. A large proportion of CTLA-4 is intracellular localized. For a complete detection it may be necessary to assess intracellular staining in addition to surface expression of CD152. | Additional information: Clone REA984 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)