Miltenyi Biotec Detection of Cd49f+ Cells; 200 µL

Miltenyi Biotec Clone REAL242 is an antibody fragment derived from the full CD49f antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REAL242 recognizes the CD49f antigen, a 120kD Single-pass type I membrane protein which is also known as Integrin alpha-6 (ITGA6). Integrins are integral cell-surface proteins composed of an α chain and a β chain and are involved in cell adhesion as well as cell-surface mediated signaling. CD49f associates with integrin β1 chain (CD29) to form VLA-6 and with integrin β4 chain (CD104) to form the α6 β4 complex, which plays a critical structural role in the hemidesmosome and constitutes a receptor for laminin in epithelial cells. CD49f is furthermore expressed on T cells, monocytes, platelets, endothelial cells, trophoblasts of placenta, and spermatogonial stem cells. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | - MLTY (Additional S&H or Hazmat Fees May Apply)