Miltenyi Biotec Identification and Enumeration of Cd49d+ Cells By Flow Cytometry; 30 µg in 200 µL

Miltenyi Biotec Clone REA807 recognizes the mouse CD49d antigen, a 150 kDa integrin family member, also known as integrin α4 chain. Integrins are cell-surface receptors, expressed as heterodimers essential in various processes mediating intercellular or cell-matrix interaction. CD49d associates non-covalently with the integrin ß or ß1 (CD29) forming the complex VLA4, which is expressed on peripheral lymphocytes, thymocytes, eosinophils, basophils, mast cells, dendritic cells, and monocytes. VLA4 plays a critical role in adhesion and migration of cells into tissues by binding to its ligand VCAM-1 (CD106). Together with the ß7 integrin, CD49d forms the heterodimer LPAM-1, which is a ligand for the mucosal vascular addressin (MAdCAM-1). | Additional information: Clone REA807 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)