Miltenyi Biotec Identification and Enumeration of Bcl-2+ Cells By Flow Cytometry; 30 Tests in 60 µL

Miltenyi Biotec Clone REA872 recognizes the human Bcl-2 antigen, which is an intracellular single-pass membrane protein found primarily in the mitochondrion outer membrane, the nucleus membrane, and the endoplasmic reticulum membrane. Bcl-2 is a member of the Bcl-2 family of regulator proteins and it forms homodimers or heterodimers with other Bcl-2 family members. It suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Bcl-2 regulates cell death by controlling the mitochondrial membrane permeability and it appears to function in a feedback loop system with caspases. Caspase activity is either inhibited by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor. | Additional information: Clone REA872 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)