Miltenyi Biotec Identification and Enumeration of Cx3cr1+ Cells By Flow Cytometry; 30 Tests in 60 µL

Miltenyi Biotec Clone REA385 recognizes the human CX3C chemokine receptor 1 antigen, a 40 kDa g-protein–coupled multi-pass membrane protein also known as fractalkine receptor. CX3CR1 is expressed on natural killer (NK) cells, T cell subsets, monocytes/macrophages, dendritic cells (DCs), and some malignant epithelial cells. Binding of CX3CR1 to the membrane-bound form of the chemokine CX3CL1 promotes cell-cell adhesion, whereas the soluble form induces cell migration of CX3CR1-bearing cells such as monocytes, NK cells, T cells, DCs, and macrophages including microglia. CX3CR1 plays also an important role in the formation of transepithelial dendrites by intestinal DCs. Failure in the CX3CL1/CX3CR1 interaction may contribute to the development of several inflammatory diseases including atherosclerosis, psoriasis, rheumatoid arthritis, and experimental autoimmune myositis. | Additional information: Clone REA385 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)