Miltenyi Biotec Identification And Enumeration Of Ifnar2+ Cells By Flow Cytometry; 30 Tests in 60 mL

Miltenyi Biotec Clone REA124 recognizes the human interferon α/β receptor 2 (IFNAR2) antigen, a 100 kDa single-pass type I membrane protein that forms one of the two chains of a receptor for the type I interferons IFN-α, IFN-β, and IFN-ω. These interferons are a group of structurally and functionally related proteins, induced by viruses or double-stranded RNA and defined by their ability to establish an antiviral state in cells. IFNAR2 is expressed on most lymphocytes, monocytes, and granulocytes, although IFNAR2 expression is higher on monocytes and granulocytes than on lymphocytes. It is involved in IFN-mediated STAT1, STAT2, and STAT3 activation. The alternatively spliced isoform of IFNAR2 is a potent inhibitor of type I IFN receptor activity. | Additional information: Clone REA124 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)