Miltenyi Biotec Detection of Cd155 (Pvr)+ Cells; 200 µL

Miltenyi Biotec Clone REAL1011 is an antibody fragment derived from the full CD155 (PVR) antibody molecule. It displays no binding to Fc receptors. The recombinantly engineered antibody fragments are multimerized to form the REAdye_lease Complex to bind markers with high avidity. | Clone REA1011 recognizes the human CD155 (PVR) antigen, a Single-pass type I membrane protein also known as Poliovirus receptor or Nectin-like protein 5 (NECL-5). CD155 is composed of two Ig-like C2-type domains and one Ig-like V-type domain that is necessary for poliovirus binding and uptake. Four different isotypes (α to δ) exist, originated from alternate splicing of the CD155 mRNA. CD155 is a broadly expressed receptor which is e.g. found on monocytes, a T cell subset and neurons of the central nervous system. CD155 is also expressed on some CD34+ progenitor cells, particulary on progenitors committed in myeloid differentiation. It can interact with several ligands, such as CD226, TIGIT, CD96, vitronectin, integrin αvβ3, and PDGFR. The functions of CD155 include roles in cell adhesion, neural differentiation, and NK cell effector functions. | For removal of REAdye_lease fluorochromes for optional relabeling with different fluorochrome-conjugated REAdye_lease antibodies use the REAlease Support Kit (130-120-675). | - MLTY (Additional S&H or Hazmat Fees May Apply)