Miltenyi Biotec Identification and Enumeration of Cd328 (Siglec-7)+ Cells By Flow Cytometry; 30 Tests in 60 µL

Miltenyi Biotec Clone REA214 recognizes CD328, which is a member of sialic acid-binding immunoglobulin-like lectins (siglecs) family of trans-membrane proteins. Upon recognizing their natural ligands, the sialylated carbohydrates, siglecs generally transmit an inhibitory signal. CD328 is a 75 kDa type I trans-membrane protein and further belongs to the human CD33-related siglec receptors with sialic acid binding N-terminal Ig domain, two C2-set Ig domains, and a cytoplasmic region containing one immune-receptor tyrosine based inhibitory motif (ITIM) and one ITIM-like motif. Expression of CD328 is found on natural killer (NK) cells, monocytes, and on a small subset of CD8+/CD3+ T cells and it preferentially binds (2,8)-linked disialic acids and branched 2,6-sialyl residues. | Additional information: Clone REA214 displays negligible binding to Fc receptors. - MLTY (Additional S&H or Hazmat Fees May Apply)