Cell Signaling Cd81 (D5o2q) Rabbit mAb (Mouse Specific)

Name: Cell Signaling Cd81 (D5o2q) Rabbit mAb (Mouse Specific)
SKU: CSIG-10037S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Cd81 (D5o2q) Rabbit mAb (Mouse Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-10037S

MFG.PART: 10037S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	22
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Immunofluorescence (Immunocytochemistry): 1:200 - 1:400, Flow Cytometry (Live): 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	CD81 (D5O2Q) Rabbit mAb recognizes endogenous levels of total CD81 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro184 of mouse CD81 protein.
Background	CD81 belongs to the tetraspanin family, which is characterized by four transmembrane domains, one short extracellular domain (ECL1), and one long extracellular domain (ECL2) (1-3). Tetraspanins interact with a variety of cell surface proteins and intracellular signaling molecules in specialized tetraspanin enriched microdomains (TEMs) where they mediate a range of processes including adhesion, motility, membrane organization, and signal transduction (3). CD81, like other tetraspanins, is enriched in exosomes (4). Many research studies demonstrate a role for CD81 in lymphocyte signaling (5-7). CD81 is also a well-characterized receptor for Hepatitis C Virus and facilitates the entry of the virus into target cells (8, 9).

Specifications