Cell Signaling Shank2 Antibody

Name: Cell Signaling Shank2 Antibody
SKU: CSIG-12218S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Shank2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12218S

MFG.PART: 12218S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	M R
Sensitivity	Endogenous
Molecular Weight (kDa)	165
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SHANK2 Antibody recognizes endogenous levels of total SHANK2 protein.
Species Reactivity	Mouse, Rat
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Val537 of human SHANK2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	The SHANK family proteins, also known as proline-rich synapse-associated proteins, consist of SHANK1, SHANK2, and SHANK3. SHANK proteins act as scaffolds at the neuronal post-synaptic density (PSD) (1), where they play a critical role in PSD assembly of excitatory synapses during development (2). While recruitment of SHANK proteins to the synapse is independent of their interaction with Homer (3), proper synaptic targeting of SHANK1 is mediated by interactions between its PDZ domain and PSD proteins (4). At the synapse, SHANK proteins interact with NMDA receptors and metabotropic glutamate receptor complexes (5). Research studies have proposed the involvement of SHANK proteins in autism and neurodegenerative diseases (1).