Cell Signaling Cytochrome C (6h2.B4) Mouse mAb

Name: Cell Signaling Cytochrome C (6h2.B4) Mouse mAb
SKU: CSIG-12963S
Price: 339.36 USD

List Price $339.36 Your Price $339.36

Cell Signaling Cytochrome C (6h2.B4) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12963S

MFG.PART: 12963S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	14
Source/Isotype	Mouse IgG1
Application/Dilution	{Immunoprecipitation: 1:100, Immunofluorescence (Immunocytochemistry): 1:300}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Cytochrome c (6H2.B4) Mouse mAb recognizes endogenous levels of total cytochrome c protein by immunofluorescence. This antibody is not recommended for western blot.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant rat cytochrome c protein.
Background	Cytochrome c is a well conserved electron-transport protein and is part of the respiratory chain localized to mitochondrial intermembrane space (1). Upon apoptotic stimulation, cytochrome c released from mitochondria associates with procaspase-9 (47 kDa)/Apaf 1. This complex processes caspase-9 from inactive proenzyme to its active form (2). This event further triggers caspase-3 activation and eventually leads to apoptosis (3).

Specifications