Cell Signaling Psmd10/Gankyrin Antibody

Name: Cell Signaling Psmd10/Gankyrin Antibody
SKU: CSIG-12985S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Psmd10/Gankyrin Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-12985S

MFG.PART: 12985S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	25
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PSMD10/Gankyrin Antibody recognizes endogenous levels of total PSMD10/Gankyrin protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human PSMD10/Gankyrin protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	PSMD10/Gankyrin is an ankyrin-repeat chaperone protein that is involved in the assembly of the 19S regulatory particle of the proteasome (1). Reasearch studies have demonstrated that PSMD10 is oncogenic and is overexpressed in hepatocullar carcinomas (2). Investigators believe the oncogenicity of PSMD10 may be linked to its ability to bind and regulate the stability and activity of pRB, CDK4, MDM2, and RelA (2-5).

Specifications