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Cell Signaling Tirap (D6m9z) Rabbit mAb (Mouse Specific)
List Price
$342.39
Your Price
$342.39
Cell Signaling Tirap (D6m9z) Rabbit mAb (Mouse Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-13077S
MFG.PART:
13077S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 35 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunoprecipitation: 1:50} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | TIRAP (D6M9Z) Rabbit mAb recognizes endogenous levels of total TIRAP protein. |
| Species Reactivity | Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro17 of mouse TIRAP protein. |
| Background | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses (1-4). TLRs recognize conserved motifs found in various pathogens and mediate defense responses (5-7). Triggering of the TLR pathway leads to the activation of NF-κB and subsequent regulation of immune and inflammatory genes (4). The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the Toll/Interleukin-1 receptor (TIR) domain (1). Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM) (8-10). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK (8,11-14). Activation of IKK leads to the degradation of IκB, which normally maintains NF-κB in an inactive state by sequestering it in the cytoplasm.Toll/interleukin-1 receptor domain-containing adaptor protein (TIRAP, MAL) is a cytoplasmic protein containing an amino-terminal PIP2 binding site and a carboxy-terminal TIR domain. This adaptor protein mediates downstream signaling from associated toll-like receptors and is essential for MyD88-dependent TLR2 and TLR4 signaling (9,15-18). TIRAP is recruited to the plasma membrane by its PIP2 binding domain, where it mediates recruitment of MyD88 to initiate TLR signaling (15). |
| SKU | CSIG-13077S |
|---|---|
| Featured | No |
| Supplier Part Number | 13077S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |