Cell Signaling Drosophila Ice (Drice) Antibody

Name: Cell Signaling Drosophila Ice (Drice) Antibody
SKU: CSIG-13085S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Drosophila Ice (Drice) Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13085S

MFG.PART: 13085S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	Dm
Sensitivity	Endogenous
Molecular Weight (kDa)	38, 21
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Drosophila ICE (drICE) Antibody recognizes endogenous levels of total drICE protein, including both full-length and cleaved protein products.
Species Reactivity	D. melanogaster
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Asp230 of Drosophila ICE (drICE) protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Cell death in the fruit fly Drosophila melanogaster is regulated by many of the same stimuli as mammalian cell death (1). The Drosophila genome contains seven caspase genes; three encode initiator caspases and four encode effector caspases (reviewed in 2). drICE is a cysteine protease that cleaves baculovirus p35 and lamin DmO in vitro and acts downstream of rpr (3). drICE is proteolytically processed during apoptosis into active p21 and p12 subunits. Comparison of the in vivo activity between drICE and Dcp-1 has shown that drICE is a more effective inducer of apoptosis than Dcp-1, which plays a role in determining the rate of cell death (4).

Specifications