Cell Signaling Hyou1 Antibody

Name: Cell Signaling Hyou1 Antibody
SKU: CSIG-13452S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Hyou1 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-13452S

MFG.PART: 13452S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	150
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	HYOU1 Antibody recognizes endogenous levels of total HYOU1 protein. This antibody reacts weakly with murine and rat HYOU1.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human HYOU1 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Hypoxia up-regulated protein 1 (HYOU1, ORP150) is an endoplasmic reticulum (ER)-resident stress protein whose expression is upregulated in response to a variety of environmental conditions that promote ER stress (1,2). The amino-terminal region of HYOU1 displays extensive similarity to the ATPase domain of HSP70 family proteins, suggesting that HYOU1 contributes to maintaining proper protein folding and secretion under conditions that promote ER stress (2). Research studies have demonstrated that HYOU1 is cytoprotective and is involved in the inhibition of hypoxia-induced cell death (3).

Specifications