Cell Signaling Ikappabalpha (L35a5) Mouse mAb (Amino-Terminal Antigen) (BSA And Azide Free)

Name: Cell Signaling Ikappabalpha (L35a5) Mouse mAb (Amino-Terminal Antigen) (BSA And Azide Free)
SKU: CSIG-15595SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling Ikappabalpha (L35a5) Mouse mAb (Amino-Terminal Antigen) (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-15595SF

MFG.PART: 15595SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H M R Mk B Pg
Sensitivity	Endogenous
Molecular Weight (kDa)	39
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #4814
Specificity/Sensitivity	IκBα (L35A5) Mouse mAb (Amino-terminal Antigen) detects endogenous levels of total IκBα protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Bovine, Pig
Source/Purification	Monoclonal antibody is produced by immunizing animals with a GST-IκBα fusion protein corresponding to the amino terminus of human IκBα.
Background	The NF-κB/Rel transcription factors are present in the cytosol in an inactive state complexed with the inhibitory IκB proteins (1-3). Activation occurs via phosphorylation of IκBα at Ser32 and Ser36 followed by proteasome-mediated degradation that results in the release and nuclear translocation of active NF-κB (3-7). IκBα phosphorylation and resulting Rel-dependent transcription are activated by a highly diverse group of extracellular signals including inflammatory cytokines, growth factors, and chemokines. Kinases that phosphorylate IκB at these activating sites have been identified (8).

Specifications