Cell Signaling Arginase-2 Antibody

Name: Cell Signaling Arginase-2 Antibody
SKU: CSIG-19324S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Arginase-2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-19324S

MFG.PART: 19324S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	40
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Arginase-2 Antibody recognizes endogenous levels of total arginase-2 protein. This antibody cross-reacts with arginase-1 protein.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro338 of human arginase-2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Arginase-2 is a mitochondrial enzyme that catalyzes the hydrolysis of L-arginine to L-ornithine and urea (1). Research studies have shown that in acute myeloid leukemia (AML) patients, arginase-2 is released from AML blasts to the plasma, leading to the suppression of T-cell proliferation (2). It was also shown that arginase-2 is required for the immunosuppressive properties of neonatal CD71(+) erythroid cells, which inhibits neonatal host defense against infection (3). In addition, the expression of arginase-2 in dendritic cells is repressed by microRNA-155 during maturation (4). This repression is essential for T-cell activation and response (4).

Specifications