Cell Signaling Gata-6 (D61e4) Xp ® Rabbit mAb (Alexa Fluor ® 488 Conjugate)

Name: Cell Signaling Gata-6 (D61e4) Xp ® Rabbit mAb (Alexa Fluor ® 488 Conjugate)
SKU: CSIG-27010S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Gata-6 (D61e4) Xp ® Rabbit mAb (Alexa Fluor ® 488 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-27010S

MFG.PART: 27010S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide, and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	GATA-6 (D61E4) XP® Rabbit mAb (Alexa Fluor® 488 Conjugate) recognizes endogenous levels of total GATA-6 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human GATA-6 protein.
Background	GATA proteins comprise a group of transcription factors that are related by the presence of conserved zinc finger DNA-binding domains, which bind directly to the nucleotide sequence core element GATA (1-3). There are six vertebrate GATA proteins, designated GATA-1 to GATA-6 (3).GATA-6 plays a critical role in endoderm development (4). It is essential for development of the heart, gut, and other organs (5,6). Knockout of GATA-6 is embryonic lethal due to defects in formation of the heart tube and a failure to develop extraembryonic endoderm (4). Loss of expression, or loss of nuclear localization of GATA-6 is apparent in a large number of ovarian tumors (7).