Cell Signaling Prss15/Lonp1 (D8w1j) Rabbit mAb

Name: Cell Signaling Prss15/Lonp1 (D8w1j) Rabbit mAb
SKU: CSIG-28020S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Prss15/Lonp1 (D8w1j) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-28020S

MFG.PART: 28020S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H M R
Sensitivity	Endogenous
Molecular Weight (kDa)	106
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PRSS15/LONP1 (D8W1J) Rabbit mAb recognizes endogenous levels of total PRSS15/LONP1 protein.
Species Reactivity	Human, Mouse, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly887 of human PRSS15/LONP1 protein.
Background	PRSS15/LONP1 is an ATP-dependent serine protease that selectively degrades misfolded, misassembled, or damaged proteins in mitochondrial matrix. PRSS15/LONP1 is induced by hypoxic, proteotoxic, and endoplasmic reticulum (ER) stress to support cell survival (1). It has been reported that PRSS15/LONP1 inducibility is decreased during aging and chronic stress (2-4). PRSS15/LONP1 is found to be substantially elevated in lymphoma cells compared to resting or activated B cells, and knock-down or inhibition of PRSS15/LONP1 induces apoptosis in lymphoma cells (5). Mutation in PRSS15/LONP1 is associated with CODAS syndrome, a multi-system developmental disorder characterized by cerebral, ocular, dental, auricular, and skeletal anomalies (6).