Cell Signaling Bip (C50b12) Rabbit mAb

Name: Cell Signaling Bip (C50b12) Rabbit mAb
SKU: CSIG-3177T
Price: 153.52 USD

List Price $153.52 Your Price $153.52

Cell Signaling Bip (C50b12) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-3177T

MFG.PART: 3177T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	78
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunohistochemistry (Paraffin): 1:200, Flow Cytometry (Fixed/Permeabilized): 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #63411.
Specificity/Sensitivity	BiP (C50B12) Rabbit mAb detects endogenous levels of total BiP protein.
Species Reactivity	Human, Mouse
Source/Purification	BiP (C50B12) Rabbit mAb is produced by immunizing rabbits with a synthetic peptide corresponding to residues surrounding Gly584 of human BiP.
Background	Secretory and transmembrane proteins are synthesized on polysomes and translocated into the endoplasmic reticulum (ER). Inside the ER, these proteins are often modified by disulfide bond formation, amino-linked glycosylation and folding. To help proteins fold properly, the ER contains a pool of molecular chaperones including BiP. BiP was identified as an immunoglobulin heavy chain binding protein in pre-B cells (1,2). It was also found to be induced at the protein level by glucose starvation (3). When protein folding is disturbed inside ER, BiP synthesis is increased. Subsequently, BiP binds to misfolded proteins to prevent them from forming aggregates and assists in proper refolding (4).

Specifications