Cell Signaling Pja2 Antibody

Name: Cell Signaling Pja2 Antibody
SKU: CSIG-40180S
Price: 309.06 USD

List Price $309.06 Your Price $309.06

Cell Signaling Pja2 Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-40180S

MFG.PART: 40180S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	150
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	PJA2 Antibody recognizes endogenous levels of total PJA2 protein.
Species Reactivity	Human, Monkey
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Gly332 of human PJA2 protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	Praja-2 (PJA2/RNF131) is a RING-H2-type E3 ubiquitin ligase. PJA2 is highly expressed in neural tissue and research studies have shown that PJA2 plays a role modulating synaptic archictecture and long-term memory by promoting the ubiquitin-dependent proteolysis of NOGO-A and PKA regulatory subunits (1,2). Research studies have also shown that PJA2 sustains gliobastoma growth by driving the ubiquitin-dependent proteasomal degradation of MOB, which inactivates the LATS tumor suppressor kinase of the Hippo pathway (3).

Specifications