Cell Signaling Microcephalin-1/Brit1 (D38g5) Rabbit mAb

Name: Cell Signaling Microcephalin-1/Brit1 (D38g5) Rabbit mAb
SKU: CSIG-4120T
Price: 153.52 USD

List Price $153.52 Your Price $153.52

Cell Signaling Microcephalin-1/Brit1 (D38g5) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-4120T

MFG.PART: 4120T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H M R Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	100
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	Microcephalin-1/BRIT1 (D38G5) Rabbit mAb detects endogenous levels of total Microcephalin-1/BRIT1 protein.
Species Reactivity	Human, Mouse, Rat, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to central residues of human Microcephalin-1/BRIT1.
Background	Microcephalin-1 (MCPH1)/BRIT1 is an early DNA damage response protein named for its mutated state in the human disease primary microcephaly. BRIT1 forms damage-induced nuclear foci, is involved in DNA damage and cell cycle checkpoints as well as regulation of mitosis. BRIT1 function is necessary for DNA damage responses, and the absence of BRIT1 function leads to genome instability. A potential tumor suppressor, BRIT1 expression is reduced in human carcinomas (1-2, reviewed in 3).BRIT1 colocalizes with other DNA repair proteins (53BP1, MDC1, NBS1, ATM, RPA, and ATR) and is required for their activation (2). BRIT1 likely regulates DNA repair through chromatin remodeling in response to DNA damage, allowing access of repair proteins to DNA (4).