Cell Signaling Sv40 Large T Antigen (D1e9e) Rabbit mAb (Sepharose Bead Conjugate)

Name: Cell Signaling Sv40 Large T Antigen (D1e9e) Rabbit mAb (Sepharose Bead Conjugate)
SKU: CSIG-45159S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Sv40 Large T Antigen (D1e9e) Rabbit mAb (Sepharose Bead Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-45159S

MFG.PART: 45159S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	400 µl
Reactivity	All
Sensitivity	Endogenous
Molecular Weight (kDa)	90
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunoprecipitation: 1:20}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SV40 Large T Antigen (D1E9E) Rabbit mAb (Sepharose® Bead Conjugate) recognizes transgenic levels of total SV40 Large T Antigen protein.
Species Reactivity	All Species Expected
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Lys315 of SV40 Large T Antigen protein.
Background	Simian Virus 40 (SV40) is a small double-stranded, circular DNA tumor virus encoding three tumor antigens: large T, Small T, and 17KT. These antigens contribute to cellular transformation, an area of research where they are utilized extensively. Transformation of cells by SV40 large T antigen is mediated by its binding to the tumor suppressor proteins RB and p53 in the nucleus. Additional binding partners include p300, CBP, Cul7, IRS1, Bub1, Nbs1, and Fbw7, which also contribute to transformation (1).

Specifications