Cell Signaling Hsp27 (G31) Mouse mAb (Bsa And Azide Free)

Name: Cell Signaling Hsp27 (G31) Mouse mAb (Bsa And Azide Free)
SKU: CSIG-47289SF
Price: 851.43 USD

List Price $851.43 Your Price $851.43

Cell Signaling Hsp27 (G31) Mouse mAb (Bsa And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-47289SF

MFG.PART: 47289SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	H Mk
Sensitivity	Endogenous
Molecular Weight (kDa)	27
Source/Isotype	Mouse IgG1
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free.For standard formulation of this product see product #2402
Specificity/Sensitivity	HSP27 (G31) Mouse mAb (BSA and Azide Free) detects endogenous levels of total HSP27 protein. The antibody does not cross-react with other heat shock proteins.
Species Reactivity	Human, Monkey
Source/Purification	Monoclonal antibody is produced by immunizing animals with full length HSP27 protein.
Background	Heat shock protein (HSP) 27 is one of the small HSPs that are constitutively expressed at different levels in various cell types and tissues. Like other small HSPs, HSP27 is regulated at both the transcriptional and posttranslational levels (1). In response to stress, the HSP27 expression increases several-fold to confer cellular resistance to the adverse environmental change. HSP27 is phosphorylated at Ser15, Ser78, and Ser82 by MAPKAPK-2 as a result of the activation of the p38 MAP kinase pathway (2,3). Phosphorylation of HSP27 causes a change in its tertiary structure, which shifts from large homotypic multimers to dimers and monomers (4). It has been shown that phosphorylation and increased concentration of HSP27 modulates actin polymerization and reorganization (5,6).

Specifications