Cell Signaling Tnfrsf17/Bcma Antibody

Name: Cell Signaling Tnfrsf17/Bcma Antibody
SKU: CSIG-47988S
Price: 320.17 USD

List Price $320.17 Your Price $320.17

Cell Signaling Tnfrsf17/Bcma Antibody - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-47988S

MFG.PART: 47988S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	18, 23
Source/Isotype	Rabbit
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA and 50% glycerol. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	TNFRSF17/BCMA Antibody recognizes endogenous levels of total TNFRSF17/BCMA protein.
Species Reactivity	Human
Source/Purification	Polyclonal antibodies are produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Leu115 of human TNFRSF17/BCMA protein. Antibodies are purified by protein A and peptide affinity chromatography.
Background	B cell maturation antigen (BCMA/TNFRSF17/CD269) is a transmembrane glycoprotein and member of the TNFR superfamily (1). BCMA expression is largely restricted to the B cell lineage. Pro-survival signaling through this receptor plays a pivotal role in humoral immunity by regulating B cell maturation and plasma cell differentiation upon binding its ligands, BAFF and APRIL (2-6). BCMA is expressed in a number of B cell malignancies and has garnered much attention as a novel therapeutic target for the treatment of multiple myeloma due to its selective and elevated expression on the cell surface of malignant plasma cells (7-10).