Cell Signaling Iga (N1cla) Mouse mAb

Name: Cell Signaling Iga (N1cla) Mouse mAb
SKU: CSIG-50384S
Price: 365.62 USD

List Price $365.62 Your Price $365.62

Cell Signaling Iga (N1cla) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-50384S

MFG.PART: 50384S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{IHC Leica Bond: 1:800 - 1:3200, Immunohistochemistry (Paraffin): 1:400 - 1:1600}
Storage	Supplied as liquid tissue culture supernatant containing sodium azide as a preservative. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	IgA (N1CLA) Mouse mAb recognizes endogenous levels of IgA protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to 129 amino acids of the heavy chain constant region of human immunoglobulin A molecule.
Background	Immunoglobulin A (IgA) is one of the five major human immunoglobulin isotypes and the most abundant immunoglobulin in the mucosal immune system. The structure of IgA consists of two identical heavy chains and two identical light chains, linked by disulfide bonds. Human IgA exists as two subclasses, IgA1 and IgA2, that are structurally different in the flexible hinge region (1). The secreted form of IgA (SIgA) is the predominant mucosal antibody that contains two copies of IgA, a joining-chain (J chain), and a secretory component (SC) (2). IgA antibodies are expressed by B cells and are a part of both the innate and adaptive immune response (3). Since IgA antibodies are secreted by mucosa, they are important when studying autoimmune diseases associated with the gastrointestinal tract (4).

Specifications