Cell Signaling Srf (D71a9) Xp Rabbit mAb

Name: Cell Signaling Srf (D71a9) Xp Rabbit mAb
SKU: CSIG-5147T
Price: 156.55 USD

List Price $156.55 Your Price $156.55

Cell Signaling Srf (D71a9) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-5147T

MFG.PART: 5147T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H M R Mk Pg
Sensitivity	Endogenous
Molecular Weight (kDa)	67
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50, Chromatin IP: 1:100}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	SRF (D71A9) XP® Rabbit mAb recognizes endogenous levels of total SRF protein.
Species Reactivity	Human, Mouse, Rat, Monkey, Pig
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ser375 of human SRF protein.
Background	The serum response factor (SRF) is a 67 kDa phospho-protein that, together with auxiliary factors, modulates transcription of immediate early genes containing serum response elements at their promoters (1,2). SRF contains several phosphorylation sites (3), but functional consequences of phosphorylation have not been identified unequivocally. Several growth factor- and calcium-regulated kinases, such as p90RSK and CaM kinase IV, can phosphorylate SRF at Ser103 (4,5), and Ser103 of SRF is also a nuclear target for MAPKAP kinase 2 (6).

Specifications