Cell Signaling Dock5 (E6r9w) Rabbit mAb

Name: Cell Signaling Dock5 (E6r9w) Rabbit mAb
SKU: CSIG-56551S
Price: 351.48 USD

List Price $351.48 Your Price $351.48

Cell Signaling Dock5 (E6r9w) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-56551S

MFG.PART: 56551S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous
Molecular Weight (kDa)	215
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, Immunoprecipitation: 1:50}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	DOCK5 (E6R9W) Rabbit mAb recognizes endogenous levels of total DOCK5 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro1863 of human DOCK5 protein.
Background	Rho family small GTPases act as molecular switches, regulating processes such as cell migration, adhesion, proliferation, and differentiation. They are activated by guanine nucleotide exchange factors (GEFs), which catalyze the exchange of bound GDP for GTP, and are inhibited by GTPase activating proteins (GAPs), which catalyze the hydrolysis of GTP to GDP (1). DOCK5 (dedicator of cytokinesis 5) is a Rho family GEF that plays an essential role in generating the sealing zone, an osteoclast-specific adhesion structure that mediates bone resorption and is regulated by actin and microtubule cytoskeletal signaling. Due to its role in bone resorption, DOCK5 is a potential therapeutic target for osteoporosis (2-4).