Cell Signaling Cd14 (61d3) Mouse mAb (PE Conjugate)

Name: Cell Signaling Cd14 (61d3) Mouse mAb (PE Conjugate)
SKU: CSIG-59896S
Price: 295.93 USD

List Price $295.93 Your Price $295.93

Cell Signaling Cd14 (61d3) Mouse mAb (PE Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-59896S

MFG.PART: 59896S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	500 µl (100 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:20, Flow Cytometry (Live): 1:20}
Storage	Supplied in 10 mm NaH2PO4, 150 mm NaCl, 0.09% NaN3, 0.1% gelatin, pH7.2. This product is stable for 12 months when stored at 4ºC. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CD14 (61D3) Mouse mAb (PE Conjugate) recognizes endogenous levels of total CD14 protein. This antibody detects an epitope within the extracellular domain.
Species Reactivity	Human
Source/Purification	This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation.
Background	CD14 is a leucine-rich repeat-containing pattern recognition receptor with expression largely restricted to the monocyte/macrophage cell lineage (1). Research studies have shown that CD14 is a bacterial lipopolysaccharide (LPS) binding glycoprotein, expressed as either a GPI-linked membrane protein or a soluble plasma protein (2). LPS induces an upregulation of GPI-linked CD14 expression, which facilitates TLR4 signaling and macrophage activation in response to bacterial infection (3-5).The 61D3 antibody is widely used to identify cells of the monocyte/macrophage lineage (6).