Cell Signaling Mitf (D5) Mouse mAb

Name: Cell Signaling Mitf (D5) Mouse mAb
SKU: CSIG-60770T
Price: 151.50 USD

List Price $151.50 Your Price $151.50

Cell Signaling Mitf (D5) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-60770T

MFG.PART: 60770T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{Immunohistochemistry (Paraffin): 1:50 - 1:200, Immunofluorescence (Immunocytochemistry): 1:800 - 1:3200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	MITF (D5) Mouse mAb recognizes endogenous levels of total MITF protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a His-tagged fusion protein corresponding to an amino-terminal fragment of human MITF protein (7).
Background	Microphthalmia-associated transcription factor (MITF) is a basic helix-loop-helix leucine zipper transcription factor that is most widely known for its roles in melanocyte, ophthalmic, and osteoclast development (1-3). In humans, MITF can function as a melanoma oncogene (4) and mutations in the corresponding MITF gene are associated with Waardenburg syndrome type 2, an auditory-pigmentary syndrome characterized by developmental defects in cells derived from neural crest (5). At least 12 isoforms of MITF have been identified, which exhibit differential patterns of expression among cell and tissue types (6).

Specifications