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Cell Signaling Pspc1 (E7l8b) Rabbit mAb
List Price
$342.39
Your Price
$342.39
Cell Signaling Pspc1 (E7l8b) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)
NETA PART:
CSIG-65992S
MFG.PART:
65992S
UNSPSC:
12352203
Manufacturer:
Cell Signaling
| Size | 100 µl |
| Reactivity | H M |
| Sensitivity | Endogenous |
| Molecular Weight (kDa) | 70 |
| Source/Isotype | Rabbit IgG |
| Application/Dilution | {Western Blotting: 1:1000, Immunofluorescence (Immunocytochemistry): 1:100 - 1:400} |
| Storage | Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/mL BSA, 50% glycerol, and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. |
| Specificity/Sensitivity | PSPC1 (E7L8B) Rabbit mAb recognizes endogenous levels of total PSPC1 protein. Faint bands running around 30 kDa, 80 kDa, and 100 kDa were observed. We are unclear of the identity of these bands. |
| Species Reactivity | Human, Mouse |
| Source/Purification | Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the amino terminus of human PSPC1 protein. |
| Background | PSPC1 (paraspeckle component 1) was one of the first proteins found to be enriched in subnuclear bodies that are adjacent to but distinct from nuclear speckles, and subsequently named paraspeckles (1). PSPC1 belongs to the Drosophila melanogaster behavior protein family comprised of human splicing (DBHS) proteins, including SFPQ (splicing factor proline-glutamine rich ) and NONO (non-POU domain-containing octamer-binding protein) which are also enriched in paraspeckles (2). DBHS proteins are a unique family of RNA-binding proteins that recruit various proteins and nucleic acids involved in transcriptional activation and repression, transcript localization, splicing, and DNA damage repair (3). Important to disease, DBHS proteins bind the long noncoding RNA NEAT1 which is found to be enriched in paraspeckles. Aberrant accumulation of NEAT1 transcripts in paraspeckles has been identified in multiple tumor types, leading to a proposal that the long coding RNA, via the process of sponging, disrupts the ratio of miRNAs to target proteins, resulting in altered protein expression profiles that promote cancer (4). |
| SKU | CSIG-65992S |
|---|---|
| Featured | No |
| Supplier Part Number | 65992S |
| UM | EA |
| UNSPSC | 12352203 |
| Manufacturer | Cell Signaling |
| MSDS URL | Click here |
| Temperature | -20C |
| CountryOfOrigin | United States |
| ProductLine | CSIG |
| Qty | 1 |
| MinOrderQty | 1 |
| Weight | 7.000000 |
| Lead Time | 5 |
| Hazardous | N |
| ACT Ecolabel | No |