Cell Signaling P16 Ink4a (Bc42) Mouse mAb

Name: Cell Signaling P16 Ink4a (Bc42) Mouse mAb
SKU: CSIG-68410T
Price: 163.62 USD

List Price $163.62 Your Price $163.62

Cell Signaling P16 Ink4a (Bc42) Mouse mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-68410T

MFG.PART: 68410T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	20 µl
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{IHC Leica Bond: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:50}
Storage	Supplied in a Tris-based buffer with ~1% BSA and less than 0.1% sodium azide. Stable for 6 months when stored at 4°C. Do not aliquot the antibody.
Specificity/Sensitivity	p16 INK4A (BC42) Mouse mAb recognizes endogenous levels of total p16 INK4A protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with a prokaryotic recombinant protein corresponding to the p16 INK4A region of the p16 molecule.
Background	Members of the INK4 family of cyclin dependent kinase inhibitors include p16 INK4A, p15 INK4B, p18 INK4C, and p19 INK4D. The INK4 family members inhibit cyclin dependent kinases 4 and 6 (CDK4 and CDK6), causing cell cycle arrest in G1 phase. The INK4A-ARF-INK4B locus on chromosome 9p21, frequently lost in human cancer, encodes the INK4 family members p16 INK5A and p15 INK4B, as well as the unrelated protein, ARF (1).p16 INK4A expression, typically repressed in the absence of stress, is thought to drive cells into senescence, and p16 INK4A expression is a commonly used marker of senescent cells (2,3). p16 INK4A protein expression is often altered in human cancer, and high expression is currently used as a predictive biomarker in cervical cancer (3-5).