Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E2j5h) Rabbit mAb (Mouse Specific) (BSA And Azide Free)

Name: Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E2j5h) Rabbit mAb (Mouse Specific) (BSA And Azide Free)
SKU: CSIG-71948SF
Price: 873.65 USD

List Price $873.65 Your Price $873.65

Cell Signaling 4-1bb/Cd137/Tnfrsf9 (E2j5h) Rabbit mAb (Mouse Specific) (BSA And Azide Free) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-71948SF

MFG.PART: 71948SF

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µg
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	24-28, 40-50
Source/Isotype	Rabbit IgG
Application/Dilution	{}
Storage	Supplied in 1X PBS, BSA and Azide Free. For standard formulation of this product see product #18798.
Specificity/Sensitivity	4-1BB/CD137/TNFRSF9 (E2J5H) XP® Rabbit mAb (BSA and Azide Free) recognizes endogenous levels of total 4-1BB/CD137/TNFRSF9 protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein corresponding to the extracellular domain of mouse 4-1BB/CD137/TNFRSF9 protein.
Background	TNFRSF9 is a member of the tumor necrosis factor receptor superfamily (1,2). It is also called 4-1BB or CD137 (1, 2). 4-1BB/CD137/TNFRSF9 is expressed in activated CD4+ and CD8+ T cells, natural killer cells and dendritic cells (2-5). The ligand 4-1BBL/CD137L/TNFSF9 on antigen presenting cells binds to 4-1BB/CD137/TNFRSF9 and costimulates the activation of T cells (5). The binding of agonistic antibodies to 4-1BB/CD137/TNFRSF9 also leads to costimulation for T cell activation (5). Studies have shown the effectiveness of targeting 4-1BB/CD137/TNFRSF9 by its agonistic antibodies in cancer immunotherapy (6).

Specifications