Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific)

Name: Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific)
SKU: CSIG-72172S
Price: 354.51 USD

List Price $354.51 Your Price $354.51

Cell Signaling Cxcr5 (D6l3c) Rabbit mAb (Ihc Specific) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-72172S

MFG.PART: 72172S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl
Reactivity	H
Sensitivity	Endogenous (IHC-P)
Source/Isotype	Rabbit IgG
Application/Dilution	{Immunohistochemistry (Paraffin): 1:200}
Storage	Supplied in 10 mm sodium HEPES (pH 7.5), 150 mm NaCl, 100 µg/mL BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody. For a carrier-free (BSA and azide free) version of this product see product #99825
Specificity/Sensitivity	CXCR5 (D6L3C) Rabbit mAb recognizes endogenous levels of total CXCR5 protein.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant protein specific to the extracellular domains of human CXCR5 protein.
Background	CXCR5 is a g protein-coupled receptor belonging to the chemokine receptor subfamily (1). Upon binding of its ligand, the chemokine CXCL13, CXCR5 initiates multiple intracellular signaling pathways that regulate cell proliferation, survival, and migration (2). CXCR5 is expressed in both mature B cells and follicular helper T cells, and responds to CXCL13 gradient to control lymphocyte migration towards secondary lymphoid tissues (3). CXCR5 has also been shown to be highly expressed in primary breast tumors, in correlation with their propensity to grow and metastasize (4).