Cell Signaling Cd31 (Pecam-1) (89c2) Mouse mAb (Alexa Fluor 594 Conjugate)

Name: Cell Signaling Cd31 (Pecam-1) (89c2) Mouse mAb (Alexa Fluor 594 Conjugate)
SKU: CSIG-75261S
Price: 469.65 USD

List Price $469.65 Your Price $469.65

Cell Signaling Cd31 (Pecam-1) (89c2) Mouse mAb (Alexa Fluor 594 Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-75261S

MFG.PART: 75261S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H
Sensitivity	Endogenous
Source/Isotype	Mouse IgG1 kappa
Application/Dilution	{Immunofluorescence (Immunocytochemistry): 1:100 - 1:200}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	CD31 (PECAM-1) (89C2) Mouse mAb (Alexa Fluor® 594 Conjugate) detects endogenous levels of total CD31 protein. It does not cross-react with other related proteins.
Species Reactivity	Human
Source/Purification	Monoclonal antibody is produced by immunizing animals with recombinant human CD31 protein.
Background	CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).