Cell Signaling Phospho-Stat2 (Tyr690) (D3p2p) Rabbit mAb (PE Conjugate)

Name: Cell Signaling Phospho-Stat2 (Tyr690) (D3p2p) Rabbit mAb (PE Conjugate)
SKU: CSIG-77366S
Price: 497.93 USD

List Price $497.93 Your Price $497.93

Cell Signaling Phospho-Stat2 (Tyr690) (D3p2p) Rabbit mAb (PE Conjugate) - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-77366S

MFG.PART: 77366S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Size	100 µl (50 tests)
Reactivity	H R
Sensitivity	Endogenous
Source/Isotype	Rabbit IgG
Application/Dilution	{Flow Cytometry (Fixed/Permeabilized): 1:50}
Storage	Supplied in PBS (pH 7.2), less than 0.1% sodium azide and 2 mg/mL BSA. Store at 4°C. Do not aliquot the antibody. Protect from light. Do not freeze.
Specificity/Sensitivity	Phospho-Stat2 (D3P2P) Rabbit mAb (PE Conjugate) recognizes endogenous levels of Stat2 protein only when phosphorylated at Tyr690.
Species Reactivity	Human, Rat
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic phospho-peptide corresponding to residues surrounding Tyr690 of human Stat2 protein.
Background	Stat2 (113-kDa), originally purified from the nuclei of alpha-interferon-treated cells, is critical to the transcriptional responses induced by type I interferons, IFN-alpha/beta (1,2). Knockout mice with a targeted disruption of Stat2 have higher susceptibility to viral infection and altered responses to type I interferons (3). Stat2 is rapidly activated by phosphorylation at Tyr690 in response to stimulation by IFN-alpha/beta via associations with receptor-bound Jak kinases (4). Unlike other Stat proteins, Stat2 does not form homodimers. Instead, activated Stat2 forms a heterodimer with Stat1 and translocates to the nucleus. There, it associates with the DNA-binding protein p48 and forms the transcriptional activator complex, interferon-stimulated gene factor 3 (ISGF3), promoting transcription from the ISRE (5).