Cell Signaling Cd31 (Pecam-1) (D8v9e) Xp Rabbit mAb

Name: Cell Signaling Cd31 (Pecam-1) (D8v9e) Xp Rabbit mAb
SKU: CSIG-77699T
Price: 176.75 USD

List Price $176.75 Your Price $176.75

Cell Signaling Cd31 (Pecam-1) (D8v9e) Xp Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-77699T

MFG.PART: 77699T

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	20 µl
Reactivity	M
Sensitivity	Endogenous
Molecular Weight (kDa)	135
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000, IHC Leica Bond: 1:50 - 1:200, Immunohistochemistry (Paraffin): 1:50 - 1:200}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.For a carrier free (BSA and azide free) version of this product see product #92841.
Specificity/Sensitivity	CD31 (PECAM-1) (D8V9E) XP® Rabbit mAb recognizes endogenous levels of total CD31 (PECAM-1) protein.
Species Reactivity	Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Ala451 of mouse CD31 (PECAM-1) protein.
Background	CD31 (Platelet Endothelial Cell Adhesion Molecule-1: PECAM-1), a member of the Ig superfamily of cell adhesion molecules, is expressed by circulating platelets, monocytes, neutrophils, some T cells, and endothelial cells and modulates cell adhesion, endothelial cell migration, and angiogenesis (1). CD31 is phosphorylated on Tyr686 at the cytoplasmic carboxy-terminal tail upon various stimuli (e.g. mechanical or oxidative stress), presumably by Src family members (2). The tyrosine phosphorylation mediates associations with a number of SH2 domain-containing binding partners such as PI3 kinase, SHIP, PLCγ, and SHP-2. Thus, CD31 serves as a scaffold for various signaling molecules (3).

Specifications