Cell Signaling Lmo4 (D6v4z) Rabbit mAb

Name: Cell Signaling Lmo4 (D6v4z) Rabbit mAb
SKU: CSIG-81428S
Price: 342.39 USD

List Price $342.39 Your Price $342.39

Cell Signaling Lmo4 (D6v4z) Rabbit mAb - CSIG (Additional S&H or Hazmat Fees May Apply)

NETA PART: CSIG-81428S

MFG.PART: 81428S

UNSPSC: 12352203

Manufacturer: Cell Signaling

Description

Size	100 µl
Reactivity	H M
Sensitivity	Endogenous
Molecular Weight (kDa)	16
Source/Isotype	Rabbit IgG
Application/Dilution	{Western Blotting: 1:1000}
Storage	Supplied in 10 mM sodium HEPES (pH 7.5), 150 mM NaCl, 100 µg/ml BSA, 50% glycerol and less than 0.02% sodium azide. Store at –20°C. Do not aliquot the antibody.
Specificity/Sensitivity	LMO4 (D6V4Z) Rabbit mAb recognizes endogenous levels of total LMO4 protein.
Species Reactivity	Human, Mouse
Source/Purification	Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues near the carboxy terminus of human LMO4 protein.
Background	LMO4 is a LIM zinc-binding domain-containing protein. LMO4 cDNA was first isolated from a breast tumor cDNA library (1). This transcriptional modulator is overexpressed in several epithelial cancers such as prostate, pancreas, and breast (2-4). LMO4 exhibits pro-oncogenic activities by inducing centrosome amplification and mitotic spindle abnormalities (5). LMO4 is also expressed in the brain, in regions involved in learning and the regulation of motivated behavior. In the basolateral amygdala, LMO4 functions to negatively regulate fear learning (6). Furthermore, in the nucleus accumbens, LMO4 was found to regulate the behavioral effects of cocaine (7).

Specifications